Feb 15, 2018
Dr. Andy McMahon, director of the Stem Cell Institute, USC, and his lab published three papers in the Journal of the American Society of Nephrology (JASN) today that detail several similarities and differences in how the kidney develops in mice and humans - at the molecular, cellular and genetic levels. This massive amount of data will be crucial in helping researchers with the ultimate goal of building kidneys from human cells while working from mouse blueprints and adds a human component for kidney research that has never before been available.
At an early stage, a nephron forming in the human kidney generates an S-shaped structure. Green cells will generate the kidneys’ filtering device, and blue and red cells specialized regions responsible for distinct nephron activities. Image courtesy of Stacy Moroz and Tracy Tran/Andy McMahon Lab, USC Stem Cell
The paper citations are as follow:
Lindström NO, McMahon J, Guo J, Tran T, Guo Q, Rutledge E, Parvez RK, Saribekyan G, Schuler RE, Liao C, Kim AD, Abdelhalim A, Ruffins SW, Thornton ME, Basking L, Grubbs B, Kesselman C, McMahon AP. Conserved and Divergent Features of Human and Mouse Kidney Organogenesis. JASN. 2018 Feb 15. doi: 10.1681/ASN.2017080887
Lindström NO, Guo J, Kim AD, Tran T, Guo Q, Brandine GS, Ransick A, Parvez RK, Thornton ME, Basking L, Grubbs B, McMahon JA, Smith AD, McMahon AP. Conserved and Divergent Features of Mesenchymal Progenitor Cell Types within the Cortical Nephrogenic Niche of the Human and Mouse Kidney. JASN. 2018 Feb 15. doi: 10.1681/ASN.2017080890
Lindström NO, Tran T, Guo J, Rutledge E, Parvez RK, Thornton ME, Grubbs B, McMahon JA, McMahon AP. Conserved and Divergent Molecular and Anatomic Features of Human and Mouse Nephron Patterning. JASN. 2018 Feb 15. doi: 10.1681/ASN.2017091036
You can find all referenced images and data organized into “collections” (much like a virtual “album”) here.
These collections were made using the underlying DERIVA software that is powering the new GUDMAP data browser (which launches officially in April). Read more about collections here.
Feb 5, 2018
The (Re)Building A Kidney Consortium is happy to announce that we are ready to accept new submissions to collaborate with us via our Partnership Program.
Specifically, we are looking for additional projects in the following subject areas:
Current subject areas of interest are LIMITED to Physiologic Function and Repair/Regeneration:
1. Physiologic Function
It is critical that bioengineered devices and biologicals (e.g. organoids, bioprinted devices) developed in RBK reflect the physiologic functions of the kidney. Specialized tools and expertise are needed to help evaluate these functions. Successful applications must involve a collaboration with an existing RBK member (https://www.rebuildingakidney.org/projects) and propose to evaluate physiological function in RBK developed bioengineered devices or biologicals. Examples might include:
It remains a major focus of the RBK to better understand productive repair in response to injury. Applicants may propose either a new standalone project OR a collaboration with an existing RBK member (https://www.rebuildingakidney.org/projects). Examples might include:
For complete details about this program, go to:
Feb 2, 2018
The Genome Editing Research Program has posted several funding opportunities:
If interested, please note that the LOIs are due now and the applications are due in early April.