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About RBK

(Re)Building a Kidney (RBK) is an NIDDK-funded consortium of research projects working to optimize approaches for the isolation, expansion, and differentiation of appropriate kidney cell types and their integration into complex structures that replicate human kidney function for the purpose of kidney regeneration and repair. The RBK Data Repository houses curated data and tools generated by the RBK consortium. All data and tools in the repository are searchable and accessible via web-based interfaces, REST APIs, and program libraries.

Background

Chronic Kidney Disease (CKD) and Acute Kidney Injury (AKI) pose a substantial public health burden. Even with the best available medical therapy, deteriorating kidney function can require renal replacement therapy (dialysis, kidney transplantation), both of which have substantial morbidity and mortality. Progressive kidney disease involves failure to effectively repair injury, ineffective regeneration of critical tissues, and unchecked continuation of pathophysiologic processes. This places great importance on the development of potential alternative therapies.

Developing and implementing strategies to enhance renal repair and promote the generation of new nephrons in the postnatal organ could have a significant impact on the prevalence and progression of kidney disease.

Diagram representing the goals the RBK Consortium
Diagram representing the goals of the RBK Consortium

Such strategies include the de novo repair of nephrons, the re-generation of nephrons, and the in vitro engineering of a biological kidney. These all require diverse scientific approaches drawn from several disciplines and lines of study. However, the cross-talk between these disciplines is limited. Although our understanding of the establishment, maintenance, and differentiation of the renal progenitors is extensive, only recently has this knowledge been used to guide the in vitro induction of renal cell lineages. It has not been exploited to inform strategies to best re-cellularize an injured kidney.

Ongoing studies and new developments have produced detailed knowledge of nephron development, induction of pluripotent stem cells towards a renal cell fate, and ex-vivo programming of renal progenitor cells. The (Re)Building a Kidney consortium's goal is to coordinate and support studies that will result in the ability to generate or repair nephrons that can function within the kidney.

Research objectives

This consortium includes a wide range of projects including but not limited to studies that:

  • Identify, characterize, and evaluate progenitor cell types (embryonic and in the adult), including manipulation of iPS cells to a renal cell fate;
  • Determine the role of microenvironments to establish the cellular compartments of the kidney (including innervation, and the vasculature and lymphatic systems);
  • Study progenitor cells and microenvironment involved in productive repair in response to injury;
  • Develop and study scaffolds for use both in vivo and in vitro;
  • Evaluate methods to target cells and molecules to specific kidney locations/compartments; and
  • Establish the necessary pre-patterning of the kidney and the interaction of cellular components to boost kidney self-organization.

RBK Consortium Monitoring Board

  • Dale Abrahamson, University of Kansas Medical Center
  • Dennis Brown, Massachusetts General Hospital
  • Alison Kohan, University of Pittsburgh
  • Thomas Peterson, United Therapeutics
  • William Welch, Georgetown University
  • Kaiming Ye, State University of New York

RBK Steering Committee

The following are current members of the RBK Steering Committee

  • Joe Bonventre, Brigham and Women's Hospital/Harvard Medical School
  • Thomas Carroll, University of Texas Southwestern
  • Ondine Cleaver, University of Texas Southwestern
  • Alan Davidson, University of Auckland
  • Mark De Caestecker, Vanderbilt University Medical Center
  • Iain A. Drummond, Massachusetts General Hospital
  • Benjamin Freedman, University of Washington
  • Neil Hukriede, University of Pittsburgh
  • Benjamin D. Humphreys, Harvard Medical School
  • Donna M. Huryn, University of Pittsburgh
  • Sanjay Jain, Washington University in St Louis
  • Carl Kesselman, University of Southern California
  • Junhyong Kim, University of Pennsylvania
  • Luke Lee, Brigham Women's Hospital
  • Jennifer Lewis, Harvard
  • Denise K. Marciano, UT Southwestern Medical Center
  • Andrew McMahon, University of Southern California
  • Ryuji Morizane, Massachusetts General Hospital
  • Leif Oxburgh, Rogosin Institute
  • Jim Roberts, Lumen Bioscience
  • Lisa Satlin, Icahn School of Medicine at Mt Sinai
  • Stuart James Shankland, University of Washington
  • M. Todd Valerius, Brigham and Women’s Hospital/Harvard Medical School
  • Jason Wertheim, University of Arizona
  • Oliver Wessely, Cleveland Clinic
  • Bradley K. Yoder, University of Alabama at Birmingham

For patients visiting this site

(Re)Building a Kidney is a basic research project and we are not currently directly involved with patients at this point. However, for information that may be of use to you, we suggest visiting the following resources from the International Society for Stem Cell Research (ISSCR):

Citing RBK

Please see the Citing RBK page for complete information.