Feb 15, 2018
Dr. Andy McMahon, director of the Stem Cell Institute, USC, and his lab published three papers in the Journal of the American Society of Nephrology (JASN) today that detail several similarities and differences in how the kidney develops in mice and humans - at the molecular, cellular and genetic levels. This massive amount of data will be crucial in helping researchers with the ultimate goal of building kidneys from human cells while working from mouse blueprints and adds a human component for kidney research that has never before been available.
At an early stage, a nephron forming in the human kidney generates an S-shaped structure. Green cells will generate the kidneys’ filtering device, and blue and red cells specialized regions responsible for distinct nephron activities. Image courtesy of Stacy Moroz and Tracy Tran/Andy McMahon Lab, USC Stem Cell
The paper citations are as follow:
Lindström NO, McMahon J, Guo J, Tran T, Guo Q, Rutledge E, Parvez RK, Saribekyan G, Schuler RE, Liao C, Kim AD, Abdelhalim A, Ruffins SW, Thornton ME, Basking L, Grubbs B, Kesselman C, McMahon AP. Conserved and Divergent Features of Human and Mouse Kidney Organogenesis. JASN. 2018 Feb 15. doi: 10.1681/ASN.2017080887
Lindström NO, Guo J, Kim AD, Tran T, Guo Q, Brandine GS, Ransick A, Parvez RK, Thornton ME, Basking L, Grubbs B, McMahon JA, Smith AD, McMahon AP. Conserved and Divergent Features of Mesenchymal Progenitor Cell Types within the Cortical Nephrogenic Niche of the Human and Mouse Kidney. JASN. 2018 Feb 15. doi: 10.1681/ASN.2017080890
Lindström NO, Tran T, Guo J, Rutledge E, Parvez RK, Thornton ME, Grubbs B, McMahon JA, McMahon AP. Conserved and Divergent Molecular and Anatomic Features of Human and Mouse Nephron Patterning. JASN. 2018 Feb 15. doi: 10.1681/ASN.2017091036
You can find all referenced images and data organized into “collections” (much like a virtual “album”) here.
These collections were made using the underlying DERIVA software that is powering the new GUDMAP data browser (which launches officially in April). Read more about collections here.