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Engineering functional kidneys

Key Personnel

Jennifer Lewis (Contact PI)
Harvard University

  • Katharina Kroll
    Harvard University
  • Kayla Wolf
    Harvard University

Ryuji Morizane (PI)
Harvard University

  • Navin Gupta
    Harvard University
  • Ken Hiratsuka
    Harvard University
  • Astia Rizki Safitri
    Harvard University

Lisa Satlin (PI)
Icahn School of Medicine, Mount Sinai

  • Rolando Carrisoza-Gaytan
    Icahn School of Medicine, Mount Sinai
  • Basil Hanss
    Icahn School of Medicine, Mount Sinai

Project Description

Our overall goal is to produce functional kidney tissues by combining kidney organoids with nephrons that are micro-vascularized and connect to a collecting system with bioprinted macro-vascular and urinary outflow networks. We posit that kidney organoids would serve as ideal organ building blocks (OBBs) for creating kidney tissues with the desired cellular composition, density, microarchitecture and function provided that hierarchical (i.e., micro- to macroscale) vascular and collecting duct networks can be established within individual organoids and between organoids assembled in a 3D tissue matrix.