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Jennifer Lewis (PI)
We aim to build a 3D proximal tubule model that contains confluent epithelium, convoluted geometry, and controlled, physiologically relevant perfusion through an open lumen that is embedded within engineered ECM. Using this model, we will study the effect of proximal tubule geometry on epithelial cell structure and function to determine the optimal curvature, degree of convolution, and tubule diameter. Ultimately, we plan to create vascularized, convoluted proximal tubule models and study vectorial transport through the interstitium (ECM) between the endothelial and epithelial tubules.