RBK Projects
Phase 2 Projects (Ongoing)
- AKI Therapeutics
Neil Hukriede (Contact PI), University of Pittsburgh; Alan Davidson, University of Auckland; Mark De Caestecker, Vanderbilt University; Donna Huryn, University of Pittsburgh
- Building Extracellular Matrix Scaffolds to Induce Nephron Development
Jason A. Wertheim, University of Arizona
- Cell-specific Delivery of Novel Therapies to Enhance Glomerular Regeneration and Repair
Stuart Shankland (Contact PI), University of Washington; Benjamin J. Freedman, University of Washington; James M. Roberts, Lumen Bioscience; Oliver Wessely, Cleveland Clinic
- Coordinating Center
Carl Kesselman (Contact PI), University of Southern California/Information Sciences Institute; M. Todd Valerius, Brigham and Women’s Hospital/Harvard Medical School
- Engineering Functional Kidneys
Jennifer Lewis (Contact PI), Harvard University; Ryuji Morizane, Harvard University; Lisa Satlin, Icahn School of Medicine
- Functional Renal Engraftment
Iain Drummond (Contact PI), Mount Desert Island Biological Laboratory; Leif Oxburgh, The Rogosin Institute; Denise Marciano, University of Texas, Southwestern
- Kidney Microphysiological Analysis Platforms (MAP) to Optimize Function and Model Disease
Joseph Bonventre (Contact PI), Brigham and Women's Hospital; Luke Lee, Brigham and Women's Hospital; Jennifer Lewis, Harvard University
- Single-cell Analysis to Promote Kidney Repair
Benjamin D. Humphreys (Contact PI), Washington University in St. Louis; Junhyong Kim, University of Pennsylvania; Andrew McMahon, University of Southern California
- Visualizing Vascularization and Cell Interactions in Implanted Organoids
Leif Oxburgh (Contact PI), The Rogosin Institute; Ondine Cleaver, University of Texas, Southwestern; Tom Carroll, University of Texas, Southwestern; Denise Marciano, University of Texas, Southwestern; Bradley Yoder, University of Alabama, Birmingham
Phase 1 Projects (Completed)
Bioengineering
Cell-type specific transcriptional profiling
Coordinating Center
Endogenous Repair
Generation of complex kidney structures
Growth and differentiation
Organoids
Physiology
Protocols - Analysis of renal biopsies
Protocols - Proteomic profiling
iPSC reporter lines