RBK Partnership Project
Requirements and Submission Process

The application period has closed for the latest PPP.

Partnership Projects are requested to add value and complement ongoing studies in the RBK Consortium and must not duplicate ongoing studies. Each Partnership Project will receive funding for 1 year but may be renewed for a second year depending on progress and programmatic priority and need. The four areas for current funding are as follows:

  1. Development of protocols for single cell analysis of human renal biopsy specimens. Protocols may involve tissue in situ analyses or digestion of specimens into single cells for transcriptional or proteomic analysis.
  2. Profiling and validation of normal adult kidney cell types isolated from human tissue using FACS, laser-capture or other approaches. Omic profiling of kidney cell types will inform in vitro and in vivo efforts to recreate or regenerate these cell types within the RBK Consortium and provide the research community with detailed expression profiles of specific kidney cell types.
  3. Development of protocols for proteomic profiling of kidney cell types using platforms amenable to single cell analysis (flow cytometry, microfluidics, mass cytometry or chemical cytometry) and/or the development of proteomic imaging methods at the single cell level (e.g., SWITCH, systems-wide control of interaction time and kinetics of chemicals, CyTOF mass cytometry, etc.).
  4. Bioengineering specific components of the kidney (e.g., convoluted proximal tubule, collecting duct, interstitium, etc.), including incorporation of appropriate cell types. Cell types may be informed by the RBK Consortium

Please refer to the original funding opportunity (RFA-DK-14-010) to fully understand the objectives of the RBK Consortium, and the RBK website for abstracts describing current RBK research projects (http://rebuildingakidney.org/). Applicants are encouraged to contact current members of the RBK Consortium to discuss potential proposals to ensure applications add value to and complement ongoing RBK projects.

Budget requests should be commensurate with project needs over a two year period. International institutions and organizations are eligible for support. Currently funded RBK projects will not be supplemented by the NIDDK to provide materials (e.g., tissue samples) to new partners, thus applicants should budget for these costs. Applicants are encouraged to contact current RBK Consortium members to understand these costs and obtain letters of support, where appropriate.

Applications of 5 pages requesting up to $150,000 total costs for per year for a maximum of 2 years are due July 1, 2016 for a projected start date of October 3, 2016.

Budget

Applicants may request up to $150,000 total costs (direct costs plus indirect costs) per year. The project period is limited to two years. A second year of support is dependent on progress and needs of the RBK Consortium. A narrative justification should be provided only for any major equipment (cost greater than $5,000) deemed necessary for the proposed project. The number of awards will depend upon the number, quality, duration, and cost of the applications received.

Budget requests must include costs for the PI and at least one lab member to physically attend meetings twice a year. The next meeting is the Executive meeting to be held on Nov 20-22, 2016 in Chicago, IL, followed by an All-Hands-on-Deck meeting in San Diego, April 2017. These are required meetings.

Awards will be made as subcontracts from the RBK Hub (RFA-DK-14-009) at the University of Southern California and not directly by the NIDDK.

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Partnership Project Review

Each submitted proposal will be assigned to multiple external scientists with expertise in the area of the proposal for primary review. The RBK External Expert Panel (EEP) will provide a secondary review of all applications. Scientists from the applicant institution are in conflict and will be excluded from all stages of the review. Final funding decisions will be made by the NIDDK. All decisions are final and appeals will not be accepted for applications submitted in response to this solicitation.

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Timetable for RBK Partnership Project Selection

May 20, 2016 RFA for RBK Partnership Project Program is posted on the RBK, GUDMAP, DiaComp and other related websites, and notification of the postings is sent to all US academic and research institutions.
July 1, 2016 Deadline for submitting grants applications to the RBK Hub (Dr. Carl Kesselman)
September 12, 2016 Awardees are announced.
October 3, 2016 Projected start date for RBK Partnership Project Program Funding.

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Data Sharing

All awardees will make data, biomaterials, models, reagents, tools, resources, methods, etc. available to the RBK Consortium and the research community. The terms and timelines for sharing within the RBK Consortium; adjustments for coordination of research plans, validation of models, materials, methods and data; and sharing with the research community will be established by the RBK Steering Committee consistent with achieving the goals of the program and NIH policies and all participants are expected to adhere to these terms as a condition of award (see Policies).

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Application & Eligibility

The application is the standard PHS 398 form including cover page, abstract, detailed budget (R&R form, not a modular budget), biographical and other support pages (up to 4 pages), and research plan. Sections A-D of the research plan are limited to 5 pages. The research plan should include the following sections:

  • Specific Aims
  • Background and Significance
  • Preliminary Studies
  • Research Design and Methods
  • Literature Cited
  • Vertebrate Animals
  • Human Subjects
  • Sharing Plan
  • Letters of Support

The sharing plan should explicitly state your willingness to:

  • Participate in meetings (in person) twice a year and the monthly conference calls during the course of the award;
  • Abide by the policies established by the RBK Steering Committee including with regards to confidentiality, conflicts of interest and pre-existing intellectual property, sharing of information and resources, and cooperative interaction; and
  • Abide by the Cooperative Agreement Terms and Conditions of Award as stated in RFA-DK-14-010.

Submit an electronic version of the application via the instructions below; PDF format only please).

Eligible Project Directors/Principal Investigators: Individuals with the skills, knowledge, and resources necessary to carry out the proposed research are invited to work with their institution to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply. New investigators are encouraged to apply, but they must have a full-time faculty position or an equivalent position at non-academic institutions.

Eligible Organizations: Public/State Controlled Institution of Higher Education; Private Institution of Higher Education; Hispanic-serving Institution; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); Alaska Native and Native Hawaiian Serving Institutions; Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education); Nonprofit without 501(c)(3) IRS Status (Other than Institution of Higher Education); Non-domestic (non-U.S.) Entity; Small Business; For-Profit Organization (Other than Small Business); State Government; Regional Organization; U.S. Territory or Possession; Indian/Native American Tribal Government (Federally Recognized); Indian/Native American Tribal Government (Other than Federally Recognized); Indian/Native American Tribally Designated Organization; Eligible agencies of the Federal government; Faith-based or community based organizations.

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Policies

A summary of progress is due two months following the completion of the first funding period, and if applicable, the second funding period.

Awardees of the RBK Partnership Project Program must follow RBK policies regarding the sharing of data and resources within the consortium and with the scientific community, and agree to the terms and agreements as described in RFA-DK-14-010 and as established by the RBK Steering Committee.

Please review the following policy documents:

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Contact Information

To contact us, please fill out the form on the Contact page.

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Submission Instructions

The application period has now closed.

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FAQs

Regarding "biosketch and other support limited to 4 pages": Does this mean that you want us to compress our biosketch to 4 pages and also include an Other Support page as part of these four pages?

The application is the standard PHS 398 form including cover page, abstract, detailed budget (R&R form, not a modular budget), biographical and other support pages (up to 4 pages), and research plan. "Other Support" is part of the biosketch, therefore the page limit is 4, including the support.

On page 3 of the RFA, it states that the $150,000/yr includes direct and IDC costs. Should I include a breakdown of both direct and IDC costs?

On the form please provide the direct cost only as requested in budget pages. This amount will be less than $150,000/yr, since you will have to include the indirects to generate the total cost which will be in box 7a of page 1.

Is there a current announcement number for this to pull up the form?

This is not an NIH PA, so there is no announcement number. Just use the PHS 398 form, fill it out, convert to PDF and submit that.

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